Enbrel (etanercept) does not affect male (or female) fertility, nor does it cause liver damage. Methotrexate can cause liver damage, but not in the doses used to treat psoriatic and rheumatoid arthritis (7.5 to 25 mg per week), unless the patient drinks alcohol or has chronic hepatitis.Click to see full answer. In this way, what are the long term side effects of Enbrel? Using Enbrel long term can cause you to have side effects. However, the long-term side effects of using the medication are very similar to the short-term side effects. Some side effects include: respiratory infections. Heart failure shortness of breath. feeling tired. cough. swelling in your legs and ankles. Similarly, what are the side effects of Enbrel? Common side effects of Enbrel include: Mild nausea. Vomiting. Diarrhea. Stomach pain. Headache. Redness or discomfort at the injection site. Heartburn. Weight changes. Also asked, do biologics affect the liver? A commonly used class of biologic response modifying drugs can cause acute liver injury with elevated liver enzymes, according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological Association.What does Enbrel do to the body?Enbrel (etanercept) is a tumor necrosis factor (TNF) blocker. It works by decreasing TNF, a protein produced by the immune system to helps the body fight infections. In people with autoimmune disorders, the immune system produces too much TNF and mistakenly attacks healthy cells.