The main difference between APAP and CPAP machines is how air pressure is chosen. CPAP machines are at a fixed pressure while APAPs adjust to different pressures automatically. Continuous Positive Airway Pressure or CPAP has been the long-standing leader in sleep apnea treatment.Click to see full answer. Also to know is, is APAP the same as CPAP?APAP vs. CPAP. There are several differences between APAP and CPAP machines, but the main one is that CPAP machines offer one steady airway pressure (that must be set by a doctor or sleep specialist) and APAP machines have airway pressure that can adjust automatically based on your needs.Also, what is the best APAP machine? Top picks 1 Philips Respironics DreamStation 2 ResMed AirSense 10 Elite 3 DeVilbiss IntelliPAP Auto CPAP Machine Simply so, what does an APAP machine do? APAP- or Automatic Positive Airway Pressure- is a medical grade device quite similar in function to a CPAP machine. The PAP based devices help to deliver a given prescribed air pressure into the airways of the patient, in order to maintain the airways from collapsing.Is ResMed AirSense 10 an APAP machine? AirSense 10 Series AirSense™ 10 is one of the world’s most widely used series of CPAP and APAP machines, each designed to deliver high-quality therapy for a better night’s sleep.