The goals of the iPLEDGE REMS (risk evaluation and mitigation strategy) Program are to prevent fetal exposure to isotretinoin and to inform prescribers, pharmacists, and patients about isotretinoin’s serious risks and safe-use conditions.Click to see full answer. Regarding this, how do you use iPLEDGE?Registration and activation is a two-step process. Registration – Prescribers may obtain a registration form online from the website’s homepage or by calling 1-866-495-0654, for assistance with the online registration form. They are instructed to sign and fax the completed form to the iPLEDGE Program 1-866-495-0660. what is a requirement of the iPLEDGE program? The iPLEDGE Program requires registration of all wholesalers distributing isotretinoin, all healthcare professionals prescribing isotretinoin, all pharmacies dispensing isotretinoin, and all male and female patients prescribed isotretinoin. Subsequently, question is, why do males have to do iPLEDGE? iPledge Requirements for Men and Women. Because isotretinoin medications (like Absorica, Claravis, etc.) can cause severe birth defects when taken during pregnancy, the iPledge program was created to help reduce the number of babies born with birth defects caused by isotretinoin.How long is iPLEDGE good for?A pharmacy must activate in order to be able to authorize a prescription in iPLEDGE. The activation expires in one year from the date of activation. A pharmacy only needs to activate once a year, however, the green activation button is always available. There is no need to register every year.