– Grade 3 Severe or medically significant but not immediately life- threatening; hospitalization or prolongation of hospitalization. indicated; disabling; limiting self care ADL. – Grade 4 Life-threatening consequences; urgent intervention indicated.Click to see full answer. Also, what is a Grade 3 drug reaction? GRADE 3 (Severe) Your daily activity is markedly reduced – some assistance usually required; medical intervention/therapy required, hospitalisation or hospice care possible.Secondly, what are the types of adverse drug reactions? Hypersensitivity (allergic) reactions to drugs are examples of type B ADRs. Type A reactions were later called augmented, and type B reactions, bizarre. Two further types of reactions were eventually added: chronic reactions, which relates to both dose and time (type C), and delayed reactions (type D). Beside above, what is a severe adverse drug reaction? Severe adverse drug reactions Severe reactions include those that may be life threatening (such as liver failure, abnormal heart rhythms, certain types of allergic reactions), that result in persistent or significant disability or hospitalization, and that cause a birth defect. Severe reactions are relatively rare.What are three types of drug interactions? Drug interactions can be categorised into 3 groups: Interactions of drugs with other drugs (drug-drug interactions), Drugs with food (drug-food interactions) Drug with disease condition (drug-disease interactions).