Conditions that have been proposed to be associated with MTHFR include: cardiovascular and thromboembolic diseases (specifically blood clots, stroke, embolism, and heart attacks) depression. anxiety. bipolar disorder. schizophrenia. colon cancer. acute leukemia. chronic pain and fatigue. Click to see full answer. Keeping this in view, what does Mthfr cause?The methylenetetrahydrofolate reductase (MTHFR) gene contains the DNA code to produce the MTHFR enzyme. This test detects two of the most common mutations. When there are mutations or variations in the MTHFR gene, it can lead to serious genetic disorders such as homocystinuria, anencephaly, spina bifida, and others.Secondly, can Mthfr cause autoimmune disorders? MTHFR mutation—changes to a gene linked to an increasing number of medical conditions, including thyroid disease—has become a controversial topic among scientists. 1? The MTHFR mutation is also believed to predispose a person to certain cancers, birth defects, and autoimmune diseases. Beside above, what are the symptoms of Mthfr gene mutation? Symptoms of the MTHFR mutation may include: Digestive Issues. Migraines. Nerve Pain. Depression. Anxiety. Schizophrenia. Bipolar Disorder. Chronic Fatigue and Pain. Is Mthfr really a problem?MTHFR mutations, on the other hand, can cause health problems—but this is very rare. In individuals who do have one of these mutations, the enzyme deficiency it causes results in a potentially harmful buildup of homocysteine in the body, leading to a condition called homocystinuria.